Arylation of 2-furyl 4-fluorophenyl ketone: An extension of heck chemistry towards novel integrase inhibitors
An optimized procedure for the direct and regioselective arylation of 2-acylfurans has been developed. The versatility of this protocol has been evaluated on a series of aryl and heteroaryl halides, thus obtaining a small collection of 2,5-disubstituted f