- Process for the preparation of diphosphonate derivatives
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A process for the preparation of a compound of formula I, STR1 wherein R1 and R2 are independently C1-6 alkyl, R3 is hydroxy and R4 and R5 are independently C1-6 alkyl is disclosed. The process comprises reacting a compound of formula II, STR2 wherein R1, R2 and R3 are defined as in formula I and X is a leaving group, with a compound of formula III, STR3 wherein R4 and R5 are independently C1-6 alkyl, in the presence of a base.
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