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VTP-27999 (Hydrochloride) is a novel and selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist, a synthetic compound with potential therapeutic applications in the treatment of neurological and psychiatric disorders. It has demonstrated the ability to improve cognitive function and exhibits neuroprotective effects in preclinical studies. VTP-27999 (Hydrochloride)'s favorable pharmacokinetic properties and brain penetration make it a promising candidate for further development as a potential drug for treating neurodegenerative and cognitive disorders.

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  • 1264191-73-2 Structure
  • Basic information

    1. Product Name: VTP-27999 (Hydrochloride)
    2. Synonyms: VTP-27999 (Hydrochloride);N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamic acid methyl ester hydrochloride (1:1);Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1);VTP-27999 HCl
    3. CAS NO:1264191-73-2
    4. Molecular Formula: C26H41ClN4O5*ClH
    5. Molecular Weight:
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1264191-73-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: VTP-27999 (Hydrochloride)(CAS DataBase Reference)
    10. NIST Chemistry Reference: VTP-27999 (Hydrochloride)(1264191-73-2)
    11. EPA Substance Registry System: VTP-27999 (Hydrochloride)(1264191-73-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1264191-73-2(Hazardous Substances Data)

1264191-73-2 Usage

Uses

Used in Pharmaceutical Industry:
VTP-27999 (Hydrochloride) is used as a therapeutic agent for the treatment of neurological and psychiatric disorders such as Alzheimer's disease, schizophrenia, and cognitive impairment. It targets the α7 nAChR, enhancing cognitive function and providing neuroprotection.
Used in Neurodegenerative Disorder Treatment:
VTP-27999 (Hydrochloride) is used as a potential drug candidate for treating neurodegenerative disorders due to its ability to improve cognitive function and exhibit neuroprotective effects, making it a promising option for further development in this area.
Used in Cognitive Impairment Therapy:
VTP-27999 (Hydrochloride) is used as a cognitive enhancer, aiming to improve cognitive function in individuals with cognitive impairments, leveraging its selective agonist activity on the α7 nAChR.

Check Digit Verification of cas no

The CAS Registry Mumber 1264191-73-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,4,1,9 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1264191-73:
(9*1)+(8*2)+(7*6)+(6*4)+(5*1)+(4*9)+(3*1)+(2*7)+(1*3)=152
152 % 10 = 2
So 1264191-73-2 is a valid CAS Registry Number.

1264191-73-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1264191-73-2 SDS

1264191-73-2Downstream Products

1264191-73-2Relevant articles and documents

CRYSTALLINE SALTS OF METHYL 2- ( (R) - ( 3-CHLORO PHENYL) ( (R) -L- ( (S) -2- (METHYLAMINO) -3- ( (R) -TETRAHYDRO-2H-PYRAN-3-YL) PROPYLCARBAMOYL )

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Page/Page column 24-25, (2011/02/24)

Mucic acid salts of a compound represented by the following structural formula:(I) are disclosed. In particular, single crystalline mucic acid salts of the compound represented by structural formula (I) are characterized by a variety of properties and phy

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