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CAS

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126451-47-6

(S)-(+)-Manidipine, also known as (S)-Manidipine Hydrochloride, is the (S) stereoisomer of Manidipine, a dihydropyridine calcium channel blocker. It is characterized by its ability to block calcium channels, which leads to a reduction in blood pressure. This makes it a valuable compound in the field of pharmaceuticals, particularly for the treatment of hypertension.
Used in Pharmaceutical Industry:
(S)-(+)-Manidipine is used as an antihypertensive agent for the treatment of high blood pressure. Its mechanism of action involves blocking L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and a decrease in peripheral vascular resistance. This results in a lowering of blood pressure, making it a beneficial medication for individuals suffering from hypertension.

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  • 126451-47-6 Structure

  • Basic information

    1. Product Name: (S)-(+)-Manidipine
    2. Synonyms: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (S)-;(S)-(+)-Manidipine;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (4S)- (9CI);ANEBWFXPVPTEET-YTTGMZPUSA-N
    3. CAS NO:126451-47-6
    4. Molecular Formula: C35H38N4O6
    5. Molecular Weight: 610.7
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Dihydropyridine;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 126451-47-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-(+)-Manidipine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-(+)-Manidipine(126451-47-6)
    11. EPA Substance Registry System: (S)-(+)-Manidipine(126451-47-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 126451-47-6(Hazardous Substances Data)

126451-47-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 126451-47-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,5 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 126451-47:
(8*1)+(7*2)+(6*6)+(5*4)+(4*5)+(3*1)+(2*4)+(1*7)=116
116 % 10 = 6
So 126451-47-6 is a valid CAS Registry Number.

126451-47-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126451-47-6 SDS

126451-47-6Relevant articles and documents

Preparation method of (S)-manidipine

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Paragraph 0064; 0065; 0066, (2016/10/20)

The invention relates to a preparation method of (S)-manidipine. Particularly, racemic manidipine free alkali is taken as a raw material, a resolving agent is used, and (S)-manidipine free alkali with optical activity is obtained with a chemical salting-out method. According to the preparation method, the yield is high, the process is simple to operate, the cost is lower, and (S)-manidipine is suitable for industrial production.

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