Asymmetric synthesis and biological activity of nor-α-tocopherol, a new vitamin E analogue
The vitamin E analogues (2R,4'R,8'R)-nor-α-tocopherol (94% de) and (2RS,4'R,8'R)-nor-α-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-α-tocopherol is