Directed Lithiation of Chlorobenzenes. Regioselectivity and Application to a Short Synthesis of Benzocyclobutenes
Chlorobenzene and its OMe, OSiMe2-t-Bu, and Cl derivatives 1 were lithiated with high regioselectivity ortho to chlorine by treatment with sec-BuLi in THF at -105 deg C without complications due to benzyne formation.The lithio species thus generated under
Iwao, Masatomo
p. 3622 - 3627
(2007/10/02)
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