Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates
The kinetic enzymatic resolution of azo acetates via aminolysis with Candida antarctica lipase B has been investigated using benzylamine as amine component. The products obtained from this biotransformation in high enantiomeric purity can serve as valuable precursors for various amino alcohols, as exemplified by the synthesis of the serotonin reuptake inhibitor (S)-(+)-cericlamine.
Prechter, Agnes,Groeger, Harald,Heinrich, Markus R.
supporting information; experimental part
p. 3384 - 3387
(2012/06/01)
Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.
Dietz, Friedrich R.,Prechter, Agnes,Gr?ger, Harald,Heinrich, Markus R.
supporting information; experimental part
p. 655 - 657
(2011/03/21)
More Articles about upstream products of 1268388-11-9