Cyclization Reactions of Ethoxymethylenemalononitrile with 4-Substituted Acetoacetates
Base-catalyzed cyclization of ethoxymethylenemalononitrile 2 with substituted acetoacetates 1 a-c leads to the ethyl benzoates 3 a-c.Depending on the reaction conditions either ethyl 4-aminobenzoates 3 d-i or ethyl 4-(2,2-dicyanethylene)aminobenzoates 4 d-h are available from 2 and the 4-oxyacetoacetates 1 d-i.The preparation of the acetoacetates 1 a-c and 1 g-i is also described. - Keywords: Ethoxymethylenemalononitrile; Cyclization; Ethyl benzoates
2 -AMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS
2-Amino-pyrimidine derivatives of formula I, wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine receptor H4antagonists.
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(2009/07/18)
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