A Short synthesis of benzomorphane analgesics (±)-Metazocine and (±)-Phenazocine
A three step synthesis of (±)-metazocine and (±)-phenazocine starting with 3,4-lutidine is described. The key step involves Lewis acid promoted lithiation/electrophilic substitution reaction of N-alkyl-3,4-dimethyl- 1,2,5,6- tetrahydropyridine. Copyright
Singh, Kamal Nain,Singh, Pushpinder,Sharma, Arvind Kumar,Singh, Paramjit,Kessar, Satinder V.
experimental part
p. 3716 - 3720
(2010/12/29)
Syntheses of analgesics. XXXVII (I). An alternative synthesis of 1,2,3,4,5,6 hexahydro 8 hydroxy 2,6 methano 6,11 dimethyl 3 phenethyl 3 benzazocine [Studies on the syntheses of heterocyclic compounds. DXXI (II)]