127025-81-4

Basic information

• Product Name: 1H-Benzimidazol-5-ol,2-methyl-4-nitro-(9CI)
• Synonyms: 1H-Benzimidazol-5-ol,2-methyl-4-nitro-(9CI)
• CAS NO: 127025-81-4
• Molecular Formula: C8H7N3O3
• Molecular Weight: 193.16
• Product Categories: BENZIMIDAZOLE
• Mol File: 127025-81-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazol-5-ol,2-methyl-4-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-5-ol,2-methyl-4-nitro-(9CI)(127025-81-4)
• EPA Substance Registry System: 1H-Benzimidazol-5-ol,2-methyl-4-nitro-(9CI)(127025-81-4)

Safety Data

• Hazardous Substances Data: 127025-81-4(Hazardous Substances Data)

Upstream product

• 41292-66-4 2-methyl-5⁽⁶⁾-hydroxybenzimidazole 
• 147021-82-7 4-nitro-2,1,3-benzoselenadiazol-5-ol 
• 147021-87-2 3,4-diamino-2-nitrophenol 
• 123-54-6 acetylacetone 

Relevant articles and documents

NITRATION OF 5(6)-HYDROXYBENZIMIDAZOLE AND ITS DERIVATIVES

Nitration of 5(6)-hydroxybenzimidazole and its derivatives takes place with the formation of mono- and dinitro-derivatives; in the latter case, the primary substitution is, as a rule, in position 4.

NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS

Compounds of formula (I): STR1 wherein: n,A,R 1,R 2,R 3, and R 4 have meanings as defined herein, or a pharmaceutically acceptable salt thereof, are useful as anti-coagulants.

A useful methodology for the synthesis of 2-methyl-4-nitrobenzimidazoles

Cyclocondensation of 3-nitro-1,2-benzenediamines 2 with 2,4-pentanedione provides a convenient route for the preparation of 2-methyl-4-nitrobenzimidazoles 3. A discrepancy in the literature regarding the 5-chloro-, 5-methoxy- and 5-methyl derivatives of the title compounds is discussed.