1270295-82-3

Basic information

• Product Name: Cbz-2-Bromo-L-Phenylalanine
• Synonyms: Cbz-2-Bromo-L-Phenylalanine;Cbz-L-2-Br-Phe-OH
• CAS NO: 1270295-82-3
• Molecular Formula: C17H16BrNO4
• Molecular Weight: 378.21724
• Mol File: 1270295-82-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cbz-2-Bromo-L-Phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: Cbz-2-Bromo-L-Phenylalanine(1270295-82-3)
• EPA Substance Registry System: Cbz-2-Bromo-L-Phenylalanine(1270295-82-3)

Safety Data

• Hazardous Substances Data: 1270295-82-3(Hazardous Substances Data)

Upstream product

• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 203640-56-6 z-(RS)-Phe(2Br)-O-carbamoylmethyl 
• 203640-55-5 Z-(RS)-Phe(2Br)-OCH₂CF₃ 
• 423763-16-0 Z-(RS)-Phe(2Br)-ON=C(CH₃)2 
• 42538-40-9 (S)-2-amino-3-(2-bromophenyl)propanoic acid 
• 501-53-1 benzyl chloroformate 
• 1991-79-3 2-amino-3-(2-bromophenyl)propanoic acid 

Downstream Products

• 423763-13-7 Z-(RS)-Phe(2Br)-OCH₂CF₂CF₃ 
• 423763-14-8 Z-(RS)-Phe(2Br)-OCH₂CH₂Cl 

Relevant articles and documents

Superiority of the carbamoylmethyl ester as an acyl donor for the kinetically controlled amide-bond formation mediated by α-chymotrypsin

The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalysed kinetically controlled peptide-bond formation is demonstrated in the couplings of an inherently poor amino acid substrate, Ala, with various amino acid residues as amino components and in the couplings of non-protein amino acids such as halogenophenylalanines as carboxylic components. Furthermore, this approach is applied to the amide-bond formation between an amino acid residue and a chiral amine, which is highly diastereoselective.

α-chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach using activated esters as acyl donors in organic solvents with low water content: Incorporation of non-protein amino acids into peptides

The α-chymotrypsin-catalyzed peptide synthesis via the kinetically controlled approach using activated esters as acyl donors in orgnanic solvents with low water content was presented. The methyl esters of N-Z derivatives of racemic non-protein amino acids were chosen as carboxy components. They allowed the peptide-bond formation and optical resolution simultaneously to yield homochiral peptides. This method is useful for the incorporation of non-protein amino acids into peptides.

Remarkable effects of donor esters on the α-chymotrypsin-catalyzed couplings of inherently poor amino acid substrates

The extremely low efficiency during the α-chymotrypsin-catalyzed coupling of an inherently poor amino acid substrate, e.g., alanine, using the methyl ester as an acyl donor was significantly improved using esters such as the 2,2,2-trifluoroethyl or carbamoylmethyl ester. The ameliorating effect of the latter ester was especially significant.