127033-13-0

Basic information

• Product Name: 4-Fluoro-7-Methoxy-1-indanone
• Synonyms: 4-Fluoro-7-Methoxy-1-indanone;4-Fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one;4-Fluoro-7-methoxy-indan-1-one;4-fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one(WXC07157)
• CAS NO: 127033-13-0
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.1756632
• Mol File: 127033-13-0.mol

Chemical Properties

• Boiling Point: 316.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Fluoro-7-Methoxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-7-Methoxy-1-indanone(127033-13-0)
• EPA Substance Registry System: 4-Fluoro-7-Methoxy-1-indanone(127033-13-0)

Safety Data

• Hazardous Substances Data: 127033-13-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Fluoro-7-Methoxy-1-indanone is utilized as a reagent in the synthesis of various pharmaceutical and agrochemical products, contributing to the development of new drugs and agricultural chemicals.
Used in Research and Development:
In the fields of medicinal chemistry and drug discovery, 4-Fluoro-7-Methoxy-1-indanone serves as a valuable precursor, enabling the exploration of novel chemical entities and potential therapeutic agents.
Used as a Precursor in Organic Chemistry:
4-Fluoro-7-Methoxy-1-indanone is employed as a precursor in the production of other organic compounds, facilitating the creation of diverse chemical structures for various applications.

Upstream product

• 127033-12-9 4-fluorophenyl 3-chloropropanoate 
• 74-88-4 methyl iodide 
• 136191-16-7 4-Fluoro-7-hydroxy-indan-1-one 
• 77-78-1 dimethyl sulfate 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 91319-46-9 3-(2-fluoro-5-methoxyphenyl)propanoic acid 
• 371-41-5 4-Fluorophenol 

Downstream Products

• 127126-25-4 Benzyl-((S)-5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127126-23-2 Benzyl-((R)-5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127033-15-2 Benzyl-(5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127126-21-0 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin 
• 127126-18-5 (R)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin 
• 764616-76-4 (S)-5-Fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine 

Relevant articles and documents

Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agents

Here, we describe the synthesis and evaluation of a class of cell-permeable indeno-oxadiazolopyrazine analogs as the anticancer agents. A new and facile approach to the synthesis of substituted analogs of indeno-oxadiazolopyrazine is illustrated. We find that the designed indeno-oxadiazolopyrazines, 3, 4, 10, 11, 15, and 16, act as potent anticancer agents compared to camptothecin, topoisomerase I inhibitor. These observations suggest that the electron-donating group (methoxy) at the C-5, C-6, and C-8 positions or electron-withdrawing group (fluoro) at the C-6 and C-7 positions on the A ring of indeno-oxadiazolopyrazines is required for antiproliferative activities against MDA-MB-231, BT549, and MCF7 cell lines.

Bicyclic amino-substituted compounds

A compound of formula (I), wherein X is O, CH 2, S, SO or SO 2 ; R is F or Cl; R 1 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 2 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 3 is H, C 1 -C 6, alkyl, a pharmaceutically acceptable salt thereof, an enantiomer thereof, and a pharmaceutically acceptable salt of said enantiomer for use in therapy. A pharmaceutical preparation containing as active ingredient any one of said compounds. A process for the preparation of a compound of formula (I).