The directed ortho-lithiation of aryl tetramethylphosphorodiamidates
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Watanabe,Date,Kawanishi,Hori,Furukawa
p. 2637 - 2643
(2007/10/02)
ORTHO-LITHIATION OF PHENOLS USING THE BIS(DIMETHYLAMINO)PHOSPHORYL GROUP AS A DIRECTING GROUP
Aryl tetramethylphosphorodiamidates were effectively lithiated with sec-BuLi at -105 deg C to give ortho-lithiated species which provide ortho-substituted phosphates by treatment with a variety of electrophiles.KEYWORDS lithiation; phenol; bis(dimethylamino)phosphoryl group; phosphate; aryl tetramethylphosphorodiamidate