- A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins
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(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT ((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes.
- Orsini, Fulvia,Sello, Guido,Travaini, Elena,Di Gennaro, Patrizia
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p. 253 - 259
(2007/10/03)
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