127557-08-8

Basic information

• Product Name: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
• Synonyms: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one;3,4-Dihydro-9-Methoxy-1-benzoxepin-5(2H)-one
• CAS NO: 127557-08-8
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 127557-08-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(127557-08-8)
• EPA Substance Registry System: 9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one(127557-08-8)

Safety Data

• Hazardous Substances Data: 127557-08-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one is used as a potential pharmaceutical compound for its possible therapeutic applications. The presence of the methoxy and ketone groups may allow for interactions with biological targets, making it a candidate for drug development.
Used in Material Science:
9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one is used as a potential material in material science due to its unique chemical structure. The properties of this compound may be harnessed for the development of new materials with specific characteristics, such as improved stability or reactivity.
Used in Synthetic Chemistry:
9-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one is used as a synthetic intermediate in the preparation of more complex molecules. Its chemical structure may serve as a building block for the synthesis of other compounds with potential applications in various fields.
Note: Further details such as its physical properties, toxicity, and potential applications in various industries require more specific study and cannot be inferred just from its structure.

Upstream product

• 104215-93-2 4-(2-methoxyphenoxy)butanoic acid 
• 127557-25-9 2,3,4,5-tetrahydro-9-methoxy-5-oxo-1-benzoxepin-4-carboxylic acid ethyl ester 
• 127557-20-4 4-(2-carboxy-6-methoxyphenoxy)butanoic acid diethyl ester 
• 90-05-1 2-methoxy-phenol 
• 35030-98-9 ethyl 2-hydroxy-3-methoxybenzoate 

Relevant articles and documents

Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder

The structure-activity relationship of a series of tricyclic-sulfonamide compounds 11-32 culminating in the discovery of N-[trans-4-(4,5-dihydro-3,6- dithia-1-aza-benzo[e]azulen-2-ylamino)-cyclohexylmethyl]-methanesulfonamide (15, Lu AA33810) is reported. Compound 15 was identified as a selective and high affinity NPY5 antagonist with good oral bioavailability in mice (42%) and rats (92%). Dose dependent inhibition of feeding was observed after i.c.v. injection of the selective NPY5 agonist ([cPP1-7,NPY19-23,Ala 31,Aib32,Gln34]-hPP). In addition, ip administration of Lu AA33810 (10 mg/kg) produced antidepressant-like effects in a rat model of chronic mild stress.

The Preparation of 3,4-Dihydro-1-benzoxepin-5(2H)-ones

Several methods for the preparation of 3,4-dihydro-1-benzoxepin-5(2H)-ones are described.In addition to the desired ketones, a veriety of novel by-products have been isolated.