Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis
The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and topical analgesic.
Allen, Anna E.,MacMillan, David W. C.
p. 4260 - 4263
(2011/06/21)
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