127680-89-1

Basic information

• Product Name: 2-PIPERIDIN-1-YLISONICOTINONITRILE
• Synonyms: 2-PIPERIDIN-1-YLISONICOTINONITRILE;2-PIPERIDINOISONICOTINONITRILE;2-Piperidin-1-ylisonicotinonitrile 97%;2-(Piperidin-1-yl)pyridine-4-carbonitrile, 4-Cyano-2-(piperidin-1-yl)pyridine;2-(Piperidin-1-yl)isonicotinonitrile97%
• CAS NO: 127680-89-1
• Molecular Formula: C₁₁H₁₃N₃
• Molecular Weight: 187.24
• Mol File: 127680-89-1.mol

Chemical Properties

• Melting Point: 55 °C
• Boiling Point: 153 °C
• Flash Point: 161.4°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.14E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PIPERIDIN-1-YLISONICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDIN-1-YLISONICOTINONITRILE(127680-89-1)
• EPA Substance Registry System: 2-PIPERIDIN-1-YLISONICOTINONITRILE(127680-89-1)

Safety Data

• Hazard Codes: Harmful:
• HazardClass: IRRITANT
• Hazardous Substances Data: 127680-89-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-PIPERIDIN-1-YLISONICOTINONITRILE is used as a building block in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique structure allows for the creation of various derivatives with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2-PIPERIDIN-1-YLISONICOTINONITRILE serves as a key intermediate, facilitating the synthesis of a range of organic compounds.
Used in Anticancer Applications:
2-PIPERIDIN-1-YLISONICOTINONITRILE is used as an anti-cancer agent due to its reported properties. It is being studied for its potential to inhibit the growth of cancer cells and to be developed into effective antitumor agents.
Used in Anti-inflammatory Applications:
2-PIPERIDIN-1-YLISONICOTINONITRILE is also used in anti-inflammatory applications, leveraging its reported anti-inflammatory properties to potentially treat conditions characterized by inflammation.
Used as a Precursor in Pharmaceutical Synthesis:
2-PIPERIDIN-1-YLISONICOTINONITRILE is utilized as a precursor in the synthesis of various pharmaceuticals, indicating its versatility and importance in the development of new medicinal compounds.

InChI:InChI=1/C11H13N3/c12-9-10-4-5-13-11(8-10)14-6-2-1-3-7-14/h4-5,8H,1-3,6-7H2/p+1

Upstream product

• 110-89-4 piperidine 
• 29181-50-8 2,4-Dicyanopyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Relevant articles and documents

New pyridine derivatives as potential antimicrobial agents

A set of pyridine derivatives bearing a substituted alkylthio chain or a piperidyl ring in position 2 or 4 were synthesized, and their antimycobacterial and antifugal activities were evaluated. Chemical structures were confirmed by IR and NMR data, and by elemental analysis. Minimum inhibitory concentrations (MIC) were used for the evaluation of microbiological activity in vitro. The compounds were moderately active against both Mycobacterium tuberculosis and nontuberculous mycobacteria. The most active compound was 2-cyanomethylthiopyridine-4-carbonitrile (7) with MIC against Mycobacterium kansasii in the range of 8-4 μmol/l. The antifungal activities of the compounds were relatively low. Copyright (C) 1999 Elsevier Science S.A.

A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines

A novel synthesis of alkylaminopyridinecarbonitriles by a photoinitiated substitution reaction between pyridine-2,4-dicarbonitrile and certain amines is described.The mechanism is discussed.