127729-35-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Aminopropyl(methyl)phosphinic acid HCl is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its ability to form stable complexes with metal ions makes it a promising candidate for the development of new drugs targeting metalloenzymes and metal-based diseases.
Used in Chemical Research:
In the field of chemical research, 3-Aminopropyl(methyl)phosphinic acid HCl is used as a reagent for the preparation of various organophosphorus compounds. Its unique structure allows for the development of new materials with potential applications in catalysis, materials science, and environmental chemistry.
Used in Neuropharmacology:
3-Aminopropyl(methyl)phosphinic acid HCl acts as a highly potent agonist of GABAB receptors. It has been shown to display sedative effects in mammals and may be used in the treatment of various addictions due to neurochemical imbalances. Its interaction with GABAB receptors can help modulate neuronal activity, providing a potential therapeutic approach for addiction treatment and other neurological disorders.
Used in Drug Delivery Systems:
Similar to gallotannin, 3-Aminopropyl(methyl)phosphinic acid HCl can be employed in the development of novel drug delivery systems. Its ability to form complexes with metal ions and its compatibility with various organic and inorganic materials make it a suitable candidate for improving the delivery, bioavailability, and therapeutic outcomes of various drugs.
Biological Activity
A very potent GABA B agonist, at least ten times more active than baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ). Also GABA C antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 127729-35-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,7,2 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 127729-35:
(8*1)+(7*2)+(6*7)+(5*7)+(4*2)+(3*9)+(2*3)+(1*5)=145
145 % 10 = 5
So 127729-35-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1
127729-35-5Relevant articles and documents
Use of GABA and GABAB agonists
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, (2008/06/13)
The present invention provides methods of stimulating tissue growth, including islet cell growth, by administering GABA or a GABA agonist to act on GABAB receptors and GABAB-like receptors to activate cell replication.
Use of GABAB receptor agonists as reflux inhibitors
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, (2008/06/13)
PCT No. PCT/SE97/01555 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Sep. 15, 1997 PCT Pub. No. WO98/11885 PCT Pub. Date Mar. 26, 1998The present invention relates to the use of GABAB receptor agonists for the inhibition of transient lower esophageal sphincter relaxations, and for the treatment of gastro-esophageal reflux disease.
Substituted aminoalkylphosphinic acids
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, (2008/06/13)
P-substituted aminoalkylphosphinic acids of the formula STR1 wherein R denotes an optionally fluorinated methyl group, R1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R2 and R3 denote hydrogen or R2 denotes hydroxy, lower alkoxy or halogen and R3 is hydrogen or R2 and R3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABAB- agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
