The organocatalytic highly enantioselective Knoevenagel condensation: applications in the synthesis of various chiral amide derivatives
Abstract: In this work, efficient organocatalysts were designed, synthesized and successfully applied to the Knoevenagel condensation. In this reaction, different α-branched aldehydes were treated with various malonate compounds to give the desired produc
116 years after the discovery of the Knoevenagel condensation, the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α-branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme).
Lee, Anna,Michrowska, Anna,Sulzer-Mosse, Sarah,List, Benjamin
experimental part
p. 1707 - 1710
(2011/04/22)
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