127862-88-8

Basic information

• Product Name: CBZ-L-2-FLUOROPHENYLALANINE
• Synonyms: N-Benzyloxycarbonyl-3-(2-fluorophenyl)-L-alanine;(S)-2-(((Benzyloxy)carbonyl)aMino)-3-(2-fluorophenyl)propanoic acid;2-Fluoro-N-[(phenylmethoxy)carbonyl]-L-phenylalanine
• CAS NO: 127862-88-8
• Molecular Formula: C₁₇H₁₆FNO₄
• Molecular Weight: 317.32
• Mol File: 127862-88-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CBZ-L-2-FLUOROPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-L-2-FLUOROPHENYLALANINE(127862-88-8)
• EPA Substance Registry System: CBZ-L-2-FLUOROPHENYLALANINE(127862-88-8)

Safety Data

• Hazardous Substances Data: 127862-88-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry Research:
CBZ-L-2-FLUOROPHENYLALANINE is used as a research tool for investigating the effects of fluorine substitution on the biological activity of amino acids and their derivatives. This is crucial for understanding how such modifications can influence protein structure and function, which is vital for the development of new pharmaceutical agents.
Used in Drug Design and Development:
In the pharmaceutical industry, CBZ-L-2-FLUOROPHENYLALANINE is used as a building block for designing new drugs with improved therapeutic properties. The incorporation of fluorine can enhance the pharmacokinetics, pharmacodynamics, and overall efficacy of drug candidates, making them more potent, selective, and stable in biological systems.
Used in Biochemical and Structural Biology Studies:
CBZ-L-2-FLUOROPHENYLALANINE is employed as a probe in biochemical and structural biology to study the impact of fluorine substitution on protein folding, stability, and interactions with other biomolecules. This can provide insights into the molecular mechanisms underlying the effects of fluorinated amino acids on biological systems.
Used in Fluorine-containing Peptide and Protein Synthesis:
CBZ-L-2-FLUOROPHENYLALANINE is used as a key component in the synthesis of fluorine-containing peptides and proteins. These modified biomolecules can exhibit altered biological activities and properties, offering opportunities for the development of novel bioactive compounds and therapeutic agents.

Upstream product

• 127862-79-7 Z-DL-Phe(2F)-OCH₂CF₃ 

Relevant articles and documents

Porcine Pancreatic Lipase Catalyzed Enantioselective Hydrolysis of Esters of N-Protected Unusual Amino Acids

Porcine pancreatic lipase catalyzed the highly enantioselective hydrolysis of a kind of α-substituted carboxylic esters, i.e., the 2,2,2-trifluoroethyl esters of the N-benzyloxycarbonyl derivatives of unusual amino acids.