Discovery, synthesis,andevaluation of small-molecule signal transducer and activator of transcription 3 inhibitors
The signal transducer and activator of transcription 3 (STAT3) oncogene is a promising molecular target and its inhibitors have great potential as anticancer drugs. To identify novel and STAT3-selective inhibitors, a virtual screening based on Specs and M
Diheterocyclic Compounds from Dithiocarbamates and Derivatives Thereof. II . 2,2'-Diamino-6,6'-Bibenzoazoles
The readily available dithiocarbamates and dithiocarbonimidates 4, 8, 14 and 15 afford in one step the title compounds in medium to good yields.In each case, the choice of reagent depends on the nature of the group to be introduced.Their usefulness as syn
Garin, Javier,Melendez, Enrique,Merchan, Francisco L.,Merino, Pedro,Orduna, Jesus,Tejero, Tomas
p. 321 - 326
(2007/10/02)
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