Asymmetric hydrogenation of α-keto acid derivatives with Rh(I)-chiral diphosphinite system. Effect of halide counterion on the asymmetric induction
A chiral diphosphinite ligand having dicyclo-hexylphosphinooxy and dimethylamino moieties (Cy-POP-AE) was effective for the asymmetric hydrogenation of N-(benzoylformyl) amino acids by a Rh(I) catalyst under mild conditions. A neutral rhodium(I) precursor enabled a double asymmetric induction in methanol, while a cationic precursor caused an asymmetric induction controlled mainly by the substrate chirality.
Yamagishi,Ikeda,Egawa,Yamaguchi,Hida
p. 281 - 283
(2007/10/02)
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