127984-94-5

Basic information

• Product Name: 1-amino-5-chloropyrimidine-2,4(1H,3H)-dione
• CAS NO: 127984-94-5
• Molecular Formula: C₄H₄ClN₃O₂
• Molecular Weight: 161.5465
• Mol File: 127984-94-5.mol

Chemical Properties

• Density: 1.72g/cm³
• Refractive Index: 1.656
• CAS DataBase Reference: 1-amino-5-chloropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-5-chloropyrimidine-2,4(1H,3H)-dione(127984-94-5)
• EPA Substance Registry System: 1-amino-5-chloropyrimidine-2,4(1H,3H)-dione(127984-94-5)

Safety Data

• Hazardous Substances Data: 127984-94-5(Hazardous Substances Data)

Upstream product

• 58990-53-7 5-chloro-2,4-bis-O-trimethylsilyluracil 
• 138481-91-1 N-(5-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide 

Downstream Products

• 142590-25-8 5-Chloro-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Anxiolytic drugs

The present invention relates to an anxiolytic drug comprising as an active ingredient a 1-amino-5-halogenouracil represented by formula [I]: STR1 wherein X represents a halogen atom, or pharmaceutically acceptable salt thereof.

1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient

Disclosed are a central nervous system depressant which comprises a 1-amino-5-halogenouracil represented by the formula STR1 wherein X represents a halogen atom, or a pharmaceutically acceptable salt thereof as an active ingredient; a 1-amino-5-halogenouracil represented by the formula STR2 wherein X' represents chlorine, bromine or iodine, or a salt thereof; and a process for preparing a 1-amino-5-halogenouracil represented by the above shown formula [I] from a pyrimidine derivative represented by the formula STR3 wherein X represents a halogen atom and R represents a protective group.

Novel uracil derivatives: Newly synthesized centrally acting agents

A series of 1-amino-5-substituted uracils and their 4-thio or 2,4-dithio substituted analogues were synthesized and assayed for anti-conflict activity in rats and anesthetic activity in mice. 1-Amino-5-halogenouracils 3b-e, 1-amino-4-thiouracil (9a), and 1-amino-5-halogeno-4-thiouracils 9c, d showed both anti-conflict and anesthetic activities. The most active compound was 1-amino-5-chloro-4-thiouracil (9d) which showed anxiolytic activity at 2 mg/kg of oral administration (p.o.) on a modified Geller-Seifter conflict schedule. Its minimum effective dose (MED) was lower than that of diazepam. The 50 percent effective dose (ED50) for anesthetic activity in mice of the compound (9d) was 32.9 mg/kg, p.o.