The present disclosure provides a compound of Formula I: or a pharmaceutically acceptable salt wherein X, R1-R8, Y1-Y5, m, n, p, and q are defined herein. The novel 2H-chromene compounds are useful for the modul
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(2016/11/14)
AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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(2015/01/07)
Synthesis of 3-(p-Fluorophenyl)-4-arylchrom-3-enes as Selective Ligands for Antiestrogen-Binding Sites
The synthesis of a series of basic ethers of 3-(p-fluorophenyl)-4-arylchrom-3-enes derived from the isofluoroflavanones is described.Preliminary biological screening shows that most of these compounds were more selective for the antiestrogenbinding sites (AEBS) than the estrogen receptor (ER) in vitro.
Teo, Chin-Chin,Kon, Oi-Lian,Sim, Keng-Yeow
p. 171 - 184
(2007/10/02)
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