128071-91-0

Basic information

• Product Name: 2,4-Dibromopyridine-3-carboxaldehyde
• Synonyms: 2,4-Dibromopyridine-3-carboxaldehyde;2,4-DibroMonicotinaldehyde;2,4-DiBromonicotincarboxaldehyde;2,4-Dibromo-3-formylpyridine;2,4-Dibromopyridine-3-carboxaldehyde 97%;2,4-DiBromopyridin-3-ylcarboxaldehyde;2,4-dibromopyridine-3-carbaldehyde
• CAS NO: 128071-91-0
• Molecular Formula: C6H3Br2NO
• Molecular Weight: 264.90212
• Mol File: 128071-91-0.mol

Chemical Properties

• Melting Point: 106-110°C
• Boiling Point: 313.4 °C at 760 mmHg
• Appearance: /
• Density: 2.09 g/cm³
• Refractive Index: 1.654
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.99±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dibromopyridine-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dibromopyridine-3-carboxaldehyde(128071-91-0)
• EPA Substance Registry System: 2,4-Dibromopyridine-3-carboxaldehyde(128071-91-0)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 128071-91-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-Dibromopyridine-3-carboxaldehyde is utilized as a key intermediate in the synthesis of various organic compounds, owing to its ability to participate in multiple reactions simultaneously. Its unique structure with bromine atoms and an aldehyde group enables it to be a valuable building block in the creation of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2,4-Dibromopyridine-3-carboxaldehyde is employed as a starting material for the development of new drugs. Its reactivity and structural features make it suitable for the synthesis of potential therapeutic agents, particularly those targeting complex biological pathways.
Used in Chemical Research:
2,4-Dibromopyridine-3-carboxaldehyde is also used as a research tool in academic and industrial laboratories. Its involvement in various types of reactions, such as aldol condensation, Wittig reaction, and Grignard reaction, provides a platform for exploring new reaction mechanisms and developing innovative synthetic strategies.
Used in Material Science:
2,4-Dibromopyridine-3-carboxaldehyde finds applications in the field of material science, where it is used to synthesize novel materials with specific properties. Its ability to undergo multiple reactions allows for the creation of materials with tailored characteristics, such as improved stability or enhanced reactivity, which can be beneficial in various applications.

InChI:InChI=1/C6H3Br2NO/c7-5-1-2-9-6(8)4(5)3-10/h1-3H

Upstream product

• 13534-89-9 2,3-dibromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 58530-53-3 2,4-dibromopyridine 

Relevant articles and documents

INHIBITOR OF BTK AND MUTANTS THEREOF

The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.