128230-76-2

Basic information

• Product Name: 2,2-DIFLUORO-1-METHYLCYCLOPROPANAMINE HYDROCHLORIDE
• Synonyms: 2,2-DIFLUORO-1-METHYLCYCLOPROPANAMINE HYDROCHLORIDE;(±)-2,2-Difluoro-1-methylcyclopropylamine hydrochloride;1-Amino-2,2-difluoro-1-methylcyclopropane hydrochloride;2,2-difluoro-1-methylcyclopropan-1-amine:hydrochloride
• CAS NO: 128230-76-2
• Molecular Formula: C4H8ClF2N
• Molecular Weight: 143.56
• Mol File: 128230-76-2.mol

Chemical Properties

• Melting Point: 143-146°C (decomposition)
• Appearance: /
• CAS DataBase Reference: 2,2-DIFLUORO-1-METHYLCYCLOPROPANAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-1-METHYLCYCLOPROPANAMINE HYDROCHLORIDE(128230-76-2)
• EPA Substance Registry System: 2,2-DIFLUORO-1-METHYLCYCLOPROPANAMINE HYDROCHLORIDE(128230-76-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT, MOISTURE SENSITIVE
• Hazardous Substances Data: 128230-76-2(Hazardous Substances Data)

Usage

Derived from

Cyclopropanamine

Contains

Two fluorine atoms, one methyl group

Hydrochloride salt form

Increases water solubility

Applications

Pharmaceutical and chemical intermediate, reagent in organic synthesis

Toxicity

Toxic if ingested or inhaled, requires proper handling precautions.

Upstream product

• 128230-73-9 2,2-Difluoro-1-methylcyclopropane isocyanate 

Relevant articles and documents

2,2-difluorocyclopropyl derivatives

2,2-Difluorocyclopropyl derivatives of the formula STR1 in which R represents alkyl, optionally substituted aryl or optionally substituted aralkyl and X represents hydroxymethyl, 2-hydroxyethyl, isocyanato, amino, amino hydrohalide or a radical of the for

Fluorinated cyclopropanecarboxylic acids and their derivatives

The addition of halofluorocarbenes such as :CF2, :CClF or :CBrF, generated from the appropriate halofluoromethanes with bases, to butadiene or isoprene gives the corresponding l-vinyl substituted halofluorocyclopropanes in moderate to good yield. The vinyl group facilitates the carbene addition and permits a subsequent wide derivatisation. Several transformations including hydroboration, oxidation and Curtius degradation are presented. Furthermore, replacement of the chlorine atom in 2-chloro-2-fluorocyclopropanecarboxylic acid derivatives by hydrogen is achieved catalytically with Raney nickel. This sequence provides a convenient route to mono-fluorine substituted cyclopropane carboxylic acids.