Synthesis of imidazo[1,2-a]pyridines: "Water-mediated" hydroamination and silver-catalyzed aminooxygenation
Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag
Silver-catalyzed cyclization of N-(prop-2-yn-1-yl)pyridin-2-amines
We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proce
Chioua, Mourad,Soriano, Elena,Infantes, Lourdes,Jimeno, M. Luisa,Marco-Contelles, Jose,Samadi, Abdelouahid
supporting information
p. 35 - 39
(2013/02/22)
Water mediated deprotective intramolecular hydroamination of N-propargylaminopyridines: Synthesis of imidazo[1,2-a]pyridines
Metal-free synthesis of substituted imidazole [1,2-a]pyridines from deprotective N-(prop-2-yn-1-yl)pyridin-2-amines in water is elucidated. Electron releasing substituents on pyridine ring provided pure products in quantitative yields without separation b
A base promoted cyclization of N-propargylaminopyridines. Synthesis of imidazo[1,2-a]pyridine derivatives
Chemical equations presented. A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a]pyridine derivatives. The reactions were carried out with a small excess of base,
Husinec, Suren,Markovic, Rade,Petkovic, Milos,Nasufovic, Veselin,Savic, Vladimir
supporting information; experimental part
p. 2286 - 2289
(2011/06/21)
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