cas 128564-66-9, 5-BROMO-1-(TRIISOPROPYLSILYL)-1H-INDOLE | Articles data ｜lookchem

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128564-66-9

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PYRROLO-PYRIDINE DERIVATIVES
Compounds of formula I are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia. STR1 wherein Q is STR2
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(2008/06/13)

The synthesis and pharmacological evaluation of indole congeners of the calcium entry blocker verapamil
Based on the notion of a bioisosteric relationship between catechol-(phenol-) and indole-amines, indole congeners of the calcium entry blocker verapamil were synthesized and examined as calcium entry blockers and as alpha1-adrenoceptor antagonists in isolated tissue preparations and as antihypertensive agents in the spontaneously hypertensive rat.Indole 27 exhibited potent calcium entry blockade in vitro and displayed antihypertensive activity, albeit slightly less than verapamil.Indole 23 possessed both calcium entry blockade and potent alpha1-adrenoceptor activity in vitro but in vivo was less active than verapamil as an antihypertensive agent.
Soll, Richard M.,Parks, James A.,Rimele, Thomas J.,Heaslip, Richard J.,Wojdan, Alexandra,et al.
p. 191 - 196
(2007/10/02)

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Chemical Properties

Boiling Point: 180oC
Flash Point:159.3oC
Density: 1.14g/cm3
Vapor Pressure: 8.99E-05mmHg at 25°C
PSA: 4.93000
LogP: 6.42740

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