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128583-07-3

6-Fluoropyridine-2-sulfonyl chloride, with the molecular formula C5H3ClFNO2S, is a pyridine derivative that serves as a key intermediate in the synthesis of pharmaceuticals and agrochemical products. This reactive and versatile building block in organic synthesis is known for its sulfonyl chloride functional group, which allows for the introduction of fluoropyridine sulfonamide moieties into organic molecules. Its importance in the pharmaceutical and agrochemical industries is underscored by its utility in creating various pyridine derivatives and heterocyclic compounds. However, due to its corrosive nature, it requires careful handling to prevent skin and eye irritation.

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  • 128583-07-3 Structure

  • Basic information

    1. Product Name: 6-FLUOROPYRIDINE-2-SULFONYL CHLORIDE
    2. Synonyms: 6-FLUOROPYRIDINE-2-SULFONYL CHLORIDE
    3. CAS NO:128583-07-3
    4. Molecular Formula: C5H3ClFNO2S
    5. Molecular Weight: 195.6
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 128583-07-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-FLUOROPYRIDINE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-FLUOROPYRIDINE-2-SULFONYL CHLORIDE(128583-07-3)
    11. EPA Substance Registry System: 6-FLUOROPYRIDINE-2-SULFONYL CHLORIDE(128583-07-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 128583-07-3(Hazardous Substances Data)

128583-07-3 Usage

Uses

Used in Pharmaceutical Industry:
6-Fluoropyridine-2-sulfonyl chloride is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its ability to introduce fluoropyridine sulfonamide moieties into organic molecules makes it a valuable reagent in the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Fluoropyridine-2-sulfonyl chloride is utilized as a key building block in the synthesis of agrochemical products. Its versatility in organic synthesis contributes to the development of new compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Organic Synthesis:
6-Fluoropyridine-2-sulfonyl chloride is used as a versatile reagent in organic synthesis for the creation of pyridine derivatives and heterocyclic compounds. Its sulfonyl chloride functional group facilitates various chemical reactions, leading to the formation of a wide range of organic molecules with diverse applications in research and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 128583-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,5,8 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 128583-07:
(8*1)+(7*2)+(6*8)+(5*5)+(4*8)+(3*3)+(2*0)+(1*7)=143
143 % 10 = 3
So 128583-07-3 is a valid CAS Registry Number.

128583-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-fluoropyridine-2-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names 6-fluoropyridine-2-sulphonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128583-07-3 SDS

128583-07-3Upstream product

128583-07-3Relevant articles and documents

N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE

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Page/Page column 190-191, (2020/07/14)

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

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Page/Page column 49, (2020/08/22)

The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

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Page/Page column 116; 117, (2018/03/25)

The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion

Nishida, Haruyuki,Fujimori, Ikuo,Arikawa, Yasuyoshi,Hirase, Keizo,Ono, Koji,Nakai, Kazuo,Inatomi, Nobuhiro,Hori, Yasunobu,Matsukawa, Jun,Fujioka, Yasushi,Imanishi, Akio,Fukui, Hideo,Itoh, Fumio

supporting information, p. 3447 - 3460 (2017/05/29)

With the aim to discover a novel excellent potassium-competitive acid blocker (P-CAB) that could perfectly overcome the limitations of proton pump inhibitors (PPIs), we tested various approaches based on pyrrole derivative 1 as a lead compound. As part of a comprehensive approach to identify a new effective drug, we tried to optimize the duration of action of the pyrrole derivative. Among the compounds synthesized, fluoropyrrole derivative 20j, which has a 2-F-3-Py group at position 5, fluorine atom at position 4, and a 4-Me-2-Py sulfonyl group at the first position of the pyrrole ring, showed potent gastric acid-suppressive action and moderate duration of action in animal models. On the basis of structural properties including a slightly larger C?log?P value (1.95), larger log?D value (0.48) at pH 7.4, and fairly similar pKa value (8.73) compared to those of the previously optimized compound 2a, compound 20j was assumed to undergo rapid transfer to the stomach and have a moderate retention time there after single administration. Therefore, compound 20j was selected as a new promising P-CAB with moderately long duration of action.

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

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Page/Page column 725-726, (2021/02/10)

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

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Paragraph 2133; 2134, (2016/05/02)

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

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Page/Page column 62-63, (2011/09/14)

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

-

Page/Page column 62-63, (2011/09/14)

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA

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Page/Page column 34-35, (2011/08/22)

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders

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Page/Page column 22, (2009/08/16)

The present invention relates to novel pyridinyl derivatives of Formula wherein Y, Z, L, R1 through R11, n, m, p, q, t are as defined herein, that are 5-HT receptor ligands, particularly the 5-HT6 subtype, and as such are useful for

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