TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE
The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.
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Paragraph 0291
(2018/05/27)
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain
Optimization of the novel alpha-2-delta-1 ligand 4 provided compounds 37 and 38 which have improved DMPK profiles, good in vivo analgesic activity and in vitro selectivity over alpha-2-delta-2. An in-house P-gp prediction programme and the MetaSite softwa
Myatt, James W.,Healy, Mark P.,Bravi, Gianpaolo S.,Billinton, Andrew,Johnson, Christopher N.,Matthews, Kim L.,Jandu, Karamjit S.,Meng, Wenjing,Hersey, Anne,Livermore, David G.,Douault, Clement B.,Witherington, Jason,Bit, Rino A.,Rowedder, James E.,Brown, Jason D.,Clayton, Nick M.
scheme or table
p. 4683 - 4688
(2010/09/18)
Einfache Synthese von 4-Acyl-5-alkyl-2,3-dioxo-2,3-dihydrofuranen und Alkylidenbutenoliden
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Saalfrank, Rolf W.,Lutz, Thomas
p. 1064 - 1066
(2007/10/02)
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