- Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA
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Alkylation under phase transfer conditions of the chiral glycine synthon 2 (prepared from the commercially available Oppolzer chiral sultam) with fluorinated analogues of 3,4-dimethoxybenzyl chloride proceeded with high diastereoselectivity. Hydrolysis of
- Deng, Wei-Ping,Wong, Kelli A.,Kirk
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p. 1135 - 1140
(2007/10/03)
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- Synthesis of 2,6-difluorodopamine and 3-(2,6-difluoro-3,4-dihydroxyphenyl)alanine
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2,6-Difluorodopamine and 3-(2,6-difluoro-3,4-dihydroxyphenyl)alanine were prepared by side-chain elaboration of 2,6-difluoroveratraldehyde, followed by removal of propecting groups. - Keywords: Synthesis; Difluorodopamine; Difluorodihydroxyphenylalanine; NMR spectroscopy; Mass spectrometry
- Nie, Jung-ying,Kirk, Kenneth L.
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p. 303 - 306
(2007/10/03)
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