128813-27-4Relevant articles and documents
Inhibitors against Fungal Cell Wall Remodeling Enzymes
Delso, Ignacio,Valero-Gonzalez, Jessika,Gomollón-Bel, Fernando,Castro-López, Jorge,Fang, Wenxia,Navratilova, Iva,van Aalten, Daan M. F.,Tejero, Tomás,Merino, Pedro,Hurtado-Guerrero, Ramon
, p. 128 - 132 (2018)
Fungal β-1,3-glucan glucanosyltransferases are glucan-remodeling enzymes that play important roles in cell wall integrity, and are essential for the viability of pathogenic fungi and yeasts. As such, they are considered possible drug targets, although inh
Enantioselective Palladium-Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides
Wang, Jun,Yang, Zhiping
supporting information, p. 27288 - 27292 (2021/11/17)
A Pd-catalyzed hydrophosphinylation of alkyl and aryl-oxyallenes with phosphine oxides has been developed for the efficient and rapid construction of a family of chiral allylic phosphine oxides with a diverse range of functional groups. This methodology was further applied in the facile construction of chiral 2H-chromene and later stage functionalization of cholesterol.
2 - (1 ', 2', 3 '- Triazole - 4' - methyl pyridine oxyalkylene) - 1, 3, 4, 6 - O - acetyl - D - glucose and its preparation method and application
-
Paragraph 0024; 0033; 0034, (2018/04/01)
The invention discloses 2-(1',2',3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose with anti-rectal cancer activity. The 2-(1',2',3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose has a core structure of 1,3,4,6-O-acetyl-D-glucose subjected to 1,2,4-triazole derivative 2-site substitution. The above compound has good rectal cancer cell inhibition activity and can be used as a drug for resisting rectal cancer. A compound synthesis method comprises that 2-amino-D-glucose hydrochloride and an azidation reagent as raw materials undergo a reaction under alkaline conditions to produce a 2-azido-1,3,4,6-O-acetyl-D-glucose intermediate, 3-propargyl bromide and aromatic methanol undergo a reaction under the action of sodium hydride to produce aromatic propargyl ether, and the 2-azido-1,3,4,6-O-acetyl-D-glucose intermediate and the aromatic propargyl ether undergo a click reaction in a solvent in the presence of monovalent copper as a catalyst to produce 2-(1', 2', 3'-triazolyl-4'-oxymethylenepyridyl)-1,3,4,6-O-acetyl-D-glucose.
Dihydroisobenzofurans and isoindolines by intramolecular inverse Diels-Alder reactions of pyridines
Biedrzycki, Marek,De Bie, Dick A.,Van Der Plas, Henk C.
, p. 607 - 614 (2007/10/02)
Pyridines being substituted at position 2 or 3 with a silylated propynyloxymethyl side-chain undergo a thermolytic intramolecular Diels-Alder reaction with formation of dihydroisobenzofurans. The 3-substituted pyridines are found to be more reactive than
