The construction of quaternary stereocenters by the Henry reaction: Circumventing the usual reactivity of substituted glyoxals
The enantioselective Henry reaction between alkyl- and arylglyoxal hydrates and nitromethane catalyzed by CuII-iminopyridine complexes takes place regioselectively on the ketone carbonyl group to give chiral tertiary nitroaldols with high functional group density and enantiomeric excesses of up to 96 %. Both aromatic and aliphatic glyoxals are suitable substrates for this reaction.
Blay, Gonzalo,Hernandez-Olmos, Victor,Pedro, Jose R.
supporting information; experimental part
p. 3768 - 3773
(2011/05/04)
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