129101-37-7Relevant articles and documents
Preparation method of chromanone 2-carboxylic acid or chroman 2-carboxylic acid derivatives
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, (2017/05/16)
The present invention relates to a chromanone-2-carboxylic acid derivative and a chroman-2-carboxylic acid derivative which can be used as an intermediate for effective medicinal components currently available in the market, and to preparation methods the
An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates
Kim, Dong Woon,Maqusood Alam,Lee, Young Hun,Khan, M. Naseer A.,Zhang, Yong,Lee, Yong Sup
, p. 912 - 917 (2015/08/24)
Chromanone-2-carboxylates and chroman-2-carboxylates are useful building blocks for the synthesis of a variety of bioactive compounds, such as repinotan, fidarestat, and nebivolol. An efficient and practical enantiospecific synthesis of chromanone-2-carboxylates and chroman-2-carboxylates has been accomplished using intramolecular Mitsunobu etherification of methyl (S)-2-hydroxy-4-oxo-4-(2′-hydroxy)phenylbutanoates derived from l-malic acid.
PROCESS FOR THE PREPARATION OF NEBIVOLOL
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Page/Page column 16-18, (2012/07/28)
The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
Method of lowering the blood pressure
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, (2008/06/13)
A method of potentiating the effects of blood pressure reducing agents in warm-blooded animals, said method comprising administering to said warm-blooded animals of an effective amount of a blood pressure reducing agent and a 2,2′-iminobisethanol derivative.