Synthesis of 3-Iodoquinolines by Copper-Catalyzed Tandem Annulation from Diaryliodoniums, Nitriles, and 1-Iodoalkynes
A novel method for the synthesis of 3-iodoquinolines was developed by copper-catalyzed tandem annulation from diaryliodoniums, nitriles, and 1-iodoalkynes. It is a method that is characterized by the most convenient operation and wide molecular diversity. (Figure presented.) .
Electrophile-driven regioselective synthesis of functionalized quinolines
Highly substituted 3-iodoquinolines bearing different alkyl and aryl moieties can be synthesized in moderate to excellent yields (up to 99%) by 6-endo-dig iodocyclization of 2-tosylaminophenylprop-1-yn-3-ols with molecular iodine (I2) under mil