129112-64-7

Basic information

• Product Name: 2-Chloro-7-nitro-3H-quinazolin-4-one
• Synonyms: 2-Chloro-7-nitro-3H-quinazolin-4-one
• CAS NO: 129112-64-7
• Molecular Formula: C₈H₄ClN₃O₃
• Molecular Weight: 225.58866
• Mol File: 129112-64-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-7-nitro-3H-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-7-nitro-3H-quinazolin-4-one(129112-64-7)
• EPA Substance Registry System: 2-Chloro-7-nitro-3H-quinazolin-4-one(129112-64-7)

Safety Data

• Hazardous Substances Data: 129112-64-7(Hazardous Substances Data)

Upstream product

• 129112-65-8 2,4-dichloro-7-nitroquinazoline 
• 619-17-0 4-Nitroanthranilic acid 
• 174565-63-0 7-nitro-1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Downstream Products

• 129112-52-3 7-Chloro-2-(4-methyl-piperazin-1-yl)-4-phenoxy-quinazoline 
• 129112-50-1 2-(4-Methyl-piperazin-1-yl)-4-phenoxy-quinazolin-7-ylamine 
• 129112-48-7 2-(4-Methyl-piperazin-1-yl)-7-nitro-4-phenoxy-quinazoline 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.

DIACYLGLYCEROL KINASE MODULATING COMPOUNDS

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents

A series of 4-phenoxy-2-(1-piperazinyl)quinazolines was synthesized and examined for anticonvulsive and antihypoxic activities. Many of the compounds exhibited potent anticonvulsive activity comparable to that of carbamazepine or phenytoin. Among them, 4-