- Construction of trifluoromethylated quaternary stereocenters: Via p -quinone methides
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Development of a new synthetic method for the construction of quaternary centers with a trifluoromethyl group was realized by way of 1,6-addition of various nucleophiles including active methylene compounds to highly reactive δ-trifluoromethylated p-quinone methides generated in situ from the corresponding tertiary carbonates with a catalytic amount of an appropriate base.
- Terashima, Kyu,Kawasaki-Takasuka, Tomoko,Agou, Tomohiro,Kubota, Toshio,Yamazaki, Takashi
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p. 3031 - 3034
(2020/03/19)
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- Multienzyme One-Pot Cascade for the Stereoselective Hydroxyethyl Functionalization of Substituted Phenols
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The operability and substrate scope of a redesigned vinylphenol hydratase as a single biocatalyst or as part of multienzyme cascades using either substituted coumaric acids or phenols as stable, cheap, and readily available substrates are reported.
- Payer, Stefan E.,Pollak, Hannah,Schmidbauer, Benjamin,Hamm, Florian,Juri?i?, Filip,Faber, Kurt,Glueck, Silvia M.
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p. 5139 - 5143
(2018/09/13)
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- Isoxazolines as Therapeutic Agents
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The present invention provides compound of Formula (I) biologically active metabolites, pro-drugs, isomers, stereoisomers, solvates, hydrates and pharmaceutically acceptable salts thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological conditions.
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Paragraph 0909
(2013/03/26)
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- Unexpected extension of usage of PPh3/CBr4, a versatile reagent: Isomerization of aromatic allylic alcohols
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The PPh3/CBr4-catalyzed isomerization of 2-aromatic allylic alcohols into the corresponding saturated aldehydes or ketones has been achieved at room temperature in good to excellent yields under mild and metal-free conditions. This new methodology has been applied successfully to the synthesis of ibuprofen in four steps.
- Gong, Wanchun,Liu, Yun,Xue, Jijun,Xie, Zhixiang,Li, Ying
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supporting information
p. 1597 - 1599
(2013/02/23)
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- Cytokine inhibitors
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Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclos
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Page/Page column 29-30
(2008/06/13)
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- Cytokine inhibitors
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Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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Page/Page column 66
(2010/02/08)
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- Cytokine inhibitors
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Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thu
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