129211-90-1

Basic information

• Product Name: 6-chloro-3-methylisothiazolo[5,4-b]pyridine
• Synonyms: 6-chloro-3-methylisothiazolo[5,4-b]pyridine
• CAS NO: 129211-90-1
• Molecular Formula: C7H5ClN2S
• Molecular Weight: 184.646
• Mol File: 129211-90-1.mol

Chemical Properties

• Boiling Point: 213.69 °C at 760 mmHg
• Flash Point: 83.037 °C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-chloro-3-methylisothiazolo[5,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-methylisothiazolo[5,4-b]pyridine(129211-90-1)
• EPA Substance Registry System: 6-chloro-3-methylisothiazolo[5,4-b]pyridine(129211-90-1)

Safety Data

• Hazardous Substances Data: 129211-90-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-3-methylisothiazolo[5,4-b]pyridine is used as an active ingredient for the development of new drugs. Its antimicrobial and antifungal properties make it a promising candidate for treating various infections and diseases.
Used in Agricultural Industry:
6-chloro-3-methylisothiazolo[5,4-b]pyridine is used as an active ingredient in agrochemicals. Its antimicrobial and antifungal properties make it useful for protecting crops from various pests and diseases, thereby increasing crop yield and quality.

InChI:InChI=1/C7H5ClN2S/c1-4-5-2-3-6(8)9-7(5)11-10-4/h2-3H,1H3

Upstream product

• 129211-88-7 4,6-Dichloro-3-methylisothiazolo<5,4-b>pyridine 
• 58315-12-1 4,6-dichloro-3-methylisoxazolo<4,5-c>pyridine 
• 129211-83-2 6-Chloro-3-(1-iminoethyl)-2-mercaptopyridin-4-ol 
• 129211-84-3 6-Chloro-3-methylisothiazolo<5,4-b>pyridin-4-ol 
• 129211-81-0 6-Chloro-3-methylisoxazolo<4,5-c>pyridine-4-thiol 
• 932702-36-8 3-methylisothiazolo[5,4-b]pyridine-N-oxide 

Relevant articles and documents

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Synthetic Investigation on Isothiazolo-- and --pyridines

Different approaches to the title ring systems were examined, based on the cleavage of the N-O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-- and --pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).