Synthesis of Polyene Bioactive Natural Products: FR252921 and Vitamin A
A formal synthesis of FR252921, a potent macrocyclic immunosuppressive agent, and a six-step synthesis of vitamin A have been demonstrated. The application of a ruthenium-catalyzed step-economic and environmentally benign strategy for the highly stereo- and chemoselective construction of valuable polyene motifs of FR252921 and vitamin A highlights the syntheses. The key features for the synthesis FR252921 include preparation of the triene moiety followed by two consecutive peptide couplings of the three fragments.
Beeralingappa, Nagabhushana C.,Dethe, Dattatraya H.,Kumar, Vimlesh,Mishra, Kunj B.,Nirpal, Appasaheb K.
supporting information
(2022/03/31)
Oxidized carotenoid fractions and ketoaldehyde useful as cell-differentiation inducers, cytostatic agents, and anti-tumor agents
This invention features fractionated oxidized carotenoid or retinoid mixtures, and individual components thereof, which are useful as cell-differentiation-inducing, anti-proliferative, anti-metastatic and anti-tumor agents. The mixtures and compounds of the invention can be used alone or in combination with other anticancer agents for the treatment of cancer.
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(2008/06/13)
Mixed peroxides from the chloroperoxidase-catalyzed oxidation of conjugated dienoic esters with a trisubstituted terminal double bond
The chloroperoxidase (CPO)-catalyzed oxidations of conjugated dienoic esters with a trisubstituted terminal double bond were studied by using tert-butyl hydroperoxide as the terminal oxidant. Most of the substrates gave disubstituted mixed peroxides as the major products.
Bougioukou, Despina J.,Smonou, Ioulia
p. 4511 - 4514
(2007/10/03)
Retinoic acid oxidation at high oxygen pressures: Evidence for spin-forbidden direct addition of triplet molecular oxygen
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Brady Clark,Howard,Oyler
p. 9560 - 9561
(2007/10/03)
Characterization of autoxidation products of retinoic acid