- Nano-TiO 2: An eco-friendly and clean reusable heterogeneous catalyst for preparation of α-aminophosphonates under ambient and solvent-free conditions
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A one-pot catalytic three-component synthesis of α-aminophosphonates from arylaldehydes, anilines, and triethylphosphite by employing TiO2 nanoparticles as a catalyst is described. Nano-TiO2 has been found to be an excellent catalyst for the green synthesis of α-aminophosphonates under ambient and solvent-free conditions. This green and mild nano catalytic procedure showed good recyclability and provides cleaner conversion in a short reaction time. These advantages make the protocol feasible and economically attractive for researchers.
- Shaterian, Hamid Reza,Farbodeh, Javad,Mohammadnia, Majid
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supporting information
p. 850 - 854
(2013/08/23)
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- Ionic liquid promoted synthesis, antibacterial and in vitro antiproliferative activity of novel α-aminophosphonate derivatives
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Ionic liquid ethyl ammonium nitrate is used as an excellent catalyst and solvent for three-component one-pot reaction of an aldehydes, amines and diethylphosphite to form novel α-aminophosphonates at room temperature. Among the various catalysts, the preparation of ethyl ammonium nitrate is an environmental friendly, cost effective and recyclable catalyst. Compounds 4b, 4c, 4d, 4f and 4j were found more potent antibacterials against pathogenic microorganisms. Whereas, compounds 4a, 4g, 4h and 4j inhibits growth of active Escherichia coli NCIM 2645 and Salmonella typhi NCIM 2501. Compound 4j was found a promising antiproliferative agent against A549 and SK-MEL2 human melanoma cell lines.
- Dake, Satish A.,Raut, Dnyaneshwar S.,Kharat, Kiran R.,Mhaske, Rooth S.,Deshmukh, Satish U.,Pawar, Rajendra P.
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experimental part
p. 2527 - 2532
(2011/06/17)
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