The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))
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Paragraph 00165; 00166
(2018/12/13)
The Chemistry of Pyrrolic Compounds. LXIII Synthetic Studies of Petroporphyrins with Fused Six-Membered Ring Systems
Several approaches to the synthesis of porphyrins bearing fused six-membered ring systems were explored with the aim of obtaining the petroporphyrin (4a).This was ultimately achieved by an intramolecular cyclization of a porphyrin with a propanoyl chloride side chain in the presence of stannic chloride.Methylation of the intermediate ketone with CH3Li and reduction of the resultant alcohol with NaBH3CN/ZnI furnished (4a).
Clezy, Peter S.,Prashar, Jognandan K.
p. 825 - 837
(2007/10/02)
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