Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate
The previously undescribed 2-desamino and 2-desamino-2-methyl analogues of aminopterin (AMT) and methotrexate (MTX) were synthesized from 2-amino-5-(chloromethyl)pyrazine-3- carbonitrile. The AMT analogues were obtained via a three-step sequence consistin
Rosowsky,Forsch,Moran,Freisheim
p. 227 - 234
(2007/10/02)
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