- DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS
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The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11β-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably R1 represents a hydrogen or OR1 represents an ester or an ether. R2 represents a naphthyl or a 1, 2, 3, 4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. R3 represents a methyl or ethyl; R4 and R'4 represent a hydrogen.
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- Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists
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Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochemical properties, new tricyclic CRF1/sub
- Gross, Raymond S.,Guo, Zhiqiang,Dyck, Brian,Coon, Tim,Huang, Charles Q.,Lowe, Richard F.,Marinkovic, Dragan,Moorjani, Manisha,Nelson, Jodene,Zamani-Kord, Said,Grigoriadis, Dimitri E.,Hoare, Sam R. J.,Crowe, Paul D.,Bu, Jane Han,Haddach, Mustapha,McCarthy, James,Saunders, John,Sullivan, Robert,Chen, TaKung,Williams, John P.
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p. 5780 - 5793
(2007/10/03)
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- IMIDAZOLIUM CXCR3 INHIBITORS
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Imidazolium compounds of formula (I); wherein: Aˉ is an anion; R1, R2 and R3 are the same or different and are hydrogen, C1-C6 alkyl, aryl, fused aryl, or heteroaryl; or are substituted aryl, fused ar
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