Synthesis of (R)-4-oxo-5-phosphononorvaline, an N-methyl-D-aspartic acid receptor selective β-keto phosphonate
(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.
Rudisill,Whitten
p. 851 - 854
(2007/10/02)
NMDA antagonists
The present invention is directed to a new class of 4-(oxoalkyl)phosphono, 4(oxime alkyl)phosphono, or 4-(hydrazine alkyl)phosphono, 2-piperazine carboxylic derivatives that are useful as NMDA antagonists
-
(2008/06/13)
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