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1300031-49-5

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METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.
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(2021/08/13)

Bromodomain Inhibitors For Treating Autoimmune And Inflammatory Diseases
The use of compounds in the treatment of autoimmune and inflammatory diseases or conditions, pharmaceutical compositions containing such compounds and to methods for identifying compounds for use in the treatment of such diseases or conditions.
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(2012/08/28)

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.
Mirguet, Olivier,Lamotte, Yann,Donche, Frédéric,Toum, Jér?me,Gellibert, Franoise,Bouillot, Anne,Gosmini, Romain,Nguyen, Van-Loc,Delannée, Delphine,Seal, Jonathan,Blandel, Florence,Boullay, Anne-Bénédicte,Boursier, Eric,Martin, Sandrine,Brusq, Jean-Marie,Krysa, Gael,Riou, Alizon,Tellier, Rémi,Costaz, Agns,Huet, Pascal,Dudit, Yann,Trottet, Lionel,Kirilovsky, Jorge,Nicodeme, Edwige
p. 2963 - 2967
(2012/06/04)

Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors
Novel compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
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(2012/09/22)

IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS
Novel compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
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(2011/06/11)

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Chemical Properties

Density: 1.314
Solubility:DMSO: soluble20mg/mL, clear
Storage Temp.:2-8°C
PKA: 11.14±0.20(Predicted)
PSA: 98.83000
LogP: 4.16250

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