130046-91-2Relevant articles and documents
A series of potent crebbp bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction
Rooney, Timothy P. C.,Filippakopoulos, Panagis,Fedorov, Oleg,Picaud, Sarah,Cortopassi, Wilian A.,Hay, Duncan A.,Martin, Sarah,Tumber, Anthony,Rogers, Catherine M.,Philpott, Martin,Wang, Minghua,Thompson, Amber L.,Heightman, Tom D.,Pryde, David C.,Cook, Andrew,Paton, Robert S.,Mueller, Susanne,Knapp, Stefan,Brennan, Paul E.,Conway, Stuart J.
supporting information, p. 6126 - 6130 (2014/06/23)
The benzoxazinone and dihydroquinoxalinone fragments were employed as novel acetyl lysine mimics in the development of CREBBP bromodomain ligands. While the benzoxazinone series showed low affinity for the CREBBP bromodomain, expansion of the dihydroquino
BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 56, (2009/08/16)
A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Method of using fluorosubstituted benzene derivatives in F-NMR imaging
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, (2008/06/13)
Fluorosubstituted benzene derivatives of Formula I STR1 wherein Y, R2, R3 and R4 are defined herein, are NMR diagnostic agents.