Synthesis of aza and carbocyclic β-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted β- And aza-β-carboline specificity
A novel two step protocol was developed to gain regiospecific access to 3-substituted β- and aza-β-carbolines, 3-PBC (1), 3-ISOPBC (2), βCCt (3), 6-aza-3-PBC (4) and 6-aza-3-ISOPBC (5). These β-carbolines (1-3) are potential clinical agents to reduce alco
Phani Babu Tiruveedhula,Methuku, Kashi Reddy,Deschamps, Jeffrey R.,Cook, James M.
p. 10705 - 10715
(2015/11/17)
Development of a two-step route to 3-PBC and βcCt, two agents active against alcohol self-administration in rodent and primate models
To gain access to 3-propoxy-β-carboline hydrochloride (3-PBC·HCl) (1·HCl) and β-carboline-3-carboxylate-tert-butyl ester (βCCt) (2), potential clinical agents active against alcohol self-administration, a two-step route was developed. This process involve
Namjoshi, Ojas A.,Gryboski, Angelica,Fonseca, German O.,Van Linn, Michael L.,Wang, Zhi-Jian,Deschamps, Jeffrey R.,Cook, James M.
experimental part
p. 4721 - 4727
(2011/07/08)
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