- METHOD FOR PRODUCING 2-AMINO-4-(TRIFLUOROMETHYL)PYRIDINE
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The present invention relates to a process for producing a 2-amino-4-trifluoromethylpyridine. Specifically, the present invention provides a process for producing a compound represented by the formula (I) or a salt thereof: (in the formula, X1 is the same as X1 in the formula (II) below), which includes allowing a compound represented by the formula (II): (in the formula, each of X1 and X2 is independently a chlorine atom or a bromine atom) to react with ammonia in the presence of a hydrophilic ether; and also a process for producing 2-amino-4-trifluoromethyl pyridine or a salt thereof, which comprises subjecting the compound of the formula (I) as produced by the foregoing process to dehalogenation,
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Page/Page column 6-7
(2012/12/13)
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- Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase
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A novel sulfonylureido pyridine series exemplified by compound 19 yielded potent inhibitors of FBPase showing significant glucose reduction and modest glycogen lowering in the acute db/db mouse model for Type-2 diabetes. Our inhibitors occupy the allosteric binding site and also extend into the dyad interface region of tetrameric FBPase.
- Hebeisen, Paul,Haap, Wolfgang,Kuhn, Bernd,Mohr, Peter,Wessel, Hans Peter,Zutter, Ulrich,Kirchner, Stephan,Ruf, Armin,Benz, J?rg,Joseph, Catherine,Alvarez-Sánchez, Rubén,Gubler, Marcel,Schott, Brigitte,Benardeau, Agnes,Tozzo, Effie,Kitas, Eric
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scheme or table
p. 3237 - 3242
(2011/07/07)
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- NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES
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Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
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Page/Page column 30
(2009/06/27)
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