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CAS

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1301738-60-2

1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1301738-60-2 Structure

  • Basic information

    1. Product Name: 1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid
    2. Synonyms: 1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid
    3. CAS NO:1301738-60-2
    4. Molecular Formula: C9H10BrNO4S2
    5. Molecular Weight: 340.214
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1301738-60-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 517.8±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.839±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.28±0.20(Predicted)
    10. CAS DataBase Reference: 1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid(1301738-60-2)
    12. EPA Substance Registry System: 1-[(5-Bromothien-2-yl)sulphonyl]pyrrolidine-2-carboxylic acid(1301738-60-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1301738-60-2(Hazardous Substances Data)

1301738-60-2 Usage

Chemical class

Pyrrolidinecarboxylic acids and derivatives

Structure

Contains a pyrrolidine ring, a carboxylic acid group, and a sulfonyl group attached to a thienyl ring with a bromine substituent

Physical properties

The presence of bromine and sulfonyl groups can impart specific physical properties to the compound

Chemical properties

The bromine and sulfonyl groups can also impart specific chemical properties to the compound

Applications

Commonly used in the field of medicinal chemistry, drug development, pharmaceutical research, and chemical synthesis

Biological activity

The thienyl ring in the structure suggests potential biological activity and may have implications for its use in drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1301738-60-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,1,7,3 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1301738-60:
(9*1)+(8*3)+(7*0)+(6*1)+(5*7)+(4*3)+(3*8)+(2*6)+(1*0)=122
122 % 10 = 2
So 1301738-60-2 is a valid CAS Registry Number.

1301738-60-2Upstream product

1301738-60-2Relevant articles and documents

Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: A potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist

Boss, Christoph,Roch-Brisbare, Catherine,Steiner, Michel A.,Treiber, Alexander,Dietrich, Hendrik,Jenck, Francois,Von Raumer, Markus,Sifferlen, Thierry,Brotschi, Christine,Heidmann, Bibia,Williams, Jodi T.,Aissaoui, Hamed,Siegrist, Romain,Gatfield, John

supporting information, p. 2486 - 2496 (2015/04/22)

The orexin system consists of two G-protein-coupled receptors, the orexin 1 and orexin 2 receptors, widely expressed in diverse regions of the brain, and two peptide agonists, orexin A and orexin B, which are produced in a small assembly of neurons in the lateral hypothalamus. The orexin system plays an important role in the maintenance of wakefulness. Several compounds (almorexant, SB-649868, suvorexant) have been in advanced clinical trials for treating primary insomnia. ACT-462206 is a new, potent, and selective dual orexin receptor antagonist (DORA) that inhibits the stimulating effects of the orexin peptides at both the orexin 1 and 2 receptors. It decreases wakefulness and increases non-rapid eye movement (non-REM) and REM sleep while maintaining natural sleep architectures in rat and dog electroencephalography/electromyography (EEG/EMG) experiments. ACT-462206 shows anxiolytic-like properties in rats without affecting cognition and motor function. It is therefore a potential candidate for the treatment of insomnia.

Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: A Potent, Brain-Penetrant Dual Orexin1/Orexin2 Receptor Antagonist

Boss, Christoph,Roch-Brisbare, Catherine,Steiner, Michel A.,Treiber, Alexander,Dietrich, Hendrik,Jenck, Francois,Vonraumer, Markus,Sifferlen, Thierry,Brotschi, Christine,Heidmann, Bibia,Williams, Jodi T.,Aissaoui, Hamed,Siegrist, Romain,Gatfield, John

supporting information, p. 2486 - 2496 (2015/08/24)

The orexin system consists of two G-protein-coupled receptors, the orexin1 and orexin2 receptors, widely expressed in diverse regions of the brain, and two peptide agonists, orexinA and orexinB, which are produced in a small assembly of neurons in the lat

PROLINE SULFONAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

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Paragraph 0252, (2013/06/27)

The present invention relates to (S)-proline sulfonamide compounds of formula (I) wherein R1 and R2 are as described in the description, or pharmaceutically acceptable salts thereof, for use in the prevention or treatment of diseases

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