130219-79-3

Basic information

• Product Name: 3-chloro-4-methylbenzo[b]thiophene
• Synonyms: 3-chloro-4-methylbenzo[b]thiophene
• CAS NO: 130219-79-3
• Molecular Formula: C9H7ClS
• Molecular Weight: 182.66988
• Mol File: 130219-79-3.mol

Chemical Properties

• Boiling Point: 280.5°C at 760 mmHg
• Flash Point: 163.1°C
• Appearance: /
• Density: 1.293g/cm³
• Vapor Pressure: 0.00641mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 3-chloro-4-methylbenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-methylbenzo[b]thiophene(130219-79-3)
• EPA Substance Registry System: 3-chloro-4-methylbenzo[b]thiophene(130219-79-3)

Safety Data

• Hazardous Substances Data: 130219-79-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7ClS/c1-6-3-2-4-8-9(6)7(10)5-11-8/h2-5H,1H3

Upstream product

• 130220-07-4 2,3-dichloro-4-methylbenzothiophene 
• 14315-11-8 4-methylbenzo[b]thiophene 
• 923772-93-4 3-chloro-4-methyl-1-benzothiophene-2-carboxylic acid 
• 935838-88-3 sodium 3-chloro-4-methylbenzo[b]thiophene-2-carboxylate 

Relevant articles and documents

3-HYDROXYMETHYLBENZO[b]THIOPHENE DERIVATIVE AND METHOD FOR PRODUCING SAME

The invention provides 3-hydroxymethylbenzo[b]thiophene derivatives useful as production intermediates for chymase inhibitors, and a process for their production. The invention relates to 3-hydroxymethylbenzo[b]thiophene derivatives represented by the following formula (II), and a process for their production.

Synthesis and Structure-Activity Relationship of Benzothienylallylamine Antimycotics

Benzothiophene analogues of the allylamine antimycotic terbinafine (2) bearing the side chain at various positions and optionally substituted by halogen have been prepared and their antifungal activity studied.Derivatives bearing the side chain at positions 3, 4, or 7 are bioequivalents of 2.Compounds containing the allylamine side chain at position 7, with a further substituent at position 3, showed significantly enhanced activity against Candida albicans, an effect which appears to be specifically linked only to this particular substitution pattern. 3-Chloro-7-benzothienyl derivative 7m was found to be the most potent allylamine antimycotic identified so far.In general, substituted benzothiophenes can be used not only as potential equivalents of naphthalene in bioactive compoudns but also as a tool to selectively modify biological activities.

Benzothienylallylamines processes for their production and their use as pharmaceuticals

Benzothienyldialkylallylamines wherein the amine side chain is attached to the ring via an alkyl radical and is either in 4-, 5-, 6- or 7-position or if not bears tertiary alkylethynyl or alkenylethynyl as its terminal group, which are useful, in particular, as anti-mycotic agents.